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1996-02-27
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Document 0585
DOCN M9630585
TI A new HTLV type II subtype A isolate in an HIV type 1-infected
prostitute from Cameroon, Central Africa.
DT 9603
AU Mauclere P; Mahieux R; Garcia-Calleja JM; Salla R; Tekaia F; Millan J;
De The G; Gessain A; Centre Pasteur du Cameroun, Yaounde.
SO AIDS Res Hum Retroviruses. 1995 Aug;11(8):989-93. Unique Identifier :
AIDSLINE GENBANK/Z46837
AB Among 332 female sex workers in Douala, Cameroon, 113 were HIV-1
seropositive, 3 were HTLV-I seropositive, and only 1 had specific
anti-HTLV-II antibodies. By cocultivation with BJAB cells, an HTLV-II
was isolated from the peripheral blood mononuclear cells of this
32-year-old woman coinfected by HIV-1. This new African HTLV-II isolate
(PH230PCAM) belongs to the molecular subtype A, exhibiting, however, a
nucleotide variability of 2.4% and 0.8%, vis-a-vis the MO prototype, in
the LTR and in the gp21 env gene, respectively. These data, as well as
the previous findings of another HTLV-II subtype A in a Ghanean
prostitute, suggest that this viral subtype had been imported into
Africa, while the HTLV-II subtype B, described in remote areas of Zaire,
Gabon, and Cameroon, could be a genuine African HTLV-II, present in this
continent for a long period of time.
DE Adult Base Sequence Cameroon Case Report Female Human HIV
Infections/*COMPLICATIONS HIV-1/*ISOLATION & PURIF
HTLV-II/GENETICS/*ISOLATION & PURIF HTLV-II
Infections/COMPLICATIONS/*VIROLOGY Molecular Sequence Data
Prostitution Support, Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).